5H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6,7-dihydro-2-(4-morpholinyl)- synthesis

4synthesis methods

Product Name:5H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6,7-dihydro-2-(4-morpholinyl)-
CAS Number:1007215-43-1
Molecular formula:C10H13ClN4O
Molecular Weight:240.69

4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine

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5H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6,7-dihydro-2-(4-morpholinyl)-

1007215-43-1
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 17 h / Reflux
2: caesium carbonate; sodium iodide / acetonitrile / 24 h / Reflux
3: sulfuric acid; trifluoroacetic acid / 5 h / Reflux

References:

Kawada, Hatsuo;Ebiike, Hirosato;Tsukazaki, Masao;Yamamoto, Shun;Koyama, Kohei;Nakamura, Mitsuaki;Morikami, Kenji;Yoshinari, Kiyoshi;Yoshida, Miyuki;Ogawa, Kotaro;Shinma, Nobuo;Tsukuda, Takuo;Ohwada, Jun [Bioorganic and Medicinal Chemistry,2015,vol. 23,# 24,p. 7650 - 7660]

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References

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References