1-Piperidineacetic acid, α-(2-fluorophenyl)-, (αR)- synthesis

2synthesis methods

Product Name:1-Piperidineacetic acid, α-(2-fluorophenyl)-, (αR)-
CAS Number:1007878-35-4
Molecular formula:C13H16FNO2
Molecular Weight:237.27

451-82-1 Synthesis

451-82-1
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1-Piperidineacetic acid, α-(2-fluorophenyl)-, (αR)-

1007878-35-4
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 - 20 °C
2.2: -78 - -10 °C
3.1: 24 h / 20 °C
4.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 2 h / 20 °C / 760.05 Torr

References:

WO2011/60000,2011,A1

Benzeneacetic acid, 2-fluoro-, (1S)-1-phenylethyl ester

1007878-31-0
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1007878-35-4
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References