![](/CAS/20150408/GIF/1009376-74-2.gif)
3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride synthesis
- Product Name:3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride
- CAS Number:1009376-74-2
- Molecular formula:C8H16ClNO2
- Molecular Weight:193.6711
![Methyl 6-methylnicotinate](/CAS/GIF/5470-70-2.gif)
5470-70-2
511 suppliers
$5.00/5g
![3-Piperidinecarboxylic acid, 6-Methyl-, Methyl ester, hydrochloride](/CAS/20150408/GIF/1009376-74-2.gif)
1009376-74-2
19 suppliers
$45.00/2.5mg
Yield:1009376-74-2 100%
Reaction Conditions:
with hydrogenchloride;hydrogen;palladium 10% on activated carbon in methanol;water at 80; under 3102.97 Torr; for 21 h;
Steps:
A; B
A 400-mL Fisher-Porter reactor was charged with methanol (300 mL), concentrated hydrochloric acid (13.0 g), 10% Pd/C (4.0 g) and methyl-6- methylnicotinate (20.0 g, 132 mmol). The mixture was heated to 80°C and placed under 60 psi hydrogen pressure. The mixture was then stirred for 21 h under these conditions. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure to give 6-Me-2 (27.0 g, quantitative). The 1H NMR spectrum was consistent with the assigned structure.
References:
WO2006/91697,2006,A1 Location in patent:Page/Page column 30; 33