![](/CAS/20150408/GIF/1012341-48-8.gif)
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid synthesis
- Product Name:(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
- CAS Number:1012341-48-8
- Molecular formula:C23H27NO4
- Molecular Weight:381.46
![(R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate](/CAS/20150408/GIF/149709-59-1.gif)
149709-59-1
90 suppliers
$11.00/100mg
![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](/CAS/20150408/GIF/1012341-48-8.gif)
1012341-48-8
205 suppliers
$9.00/1g
Yield:1012341-48-8 70%
Reaction Conditions:
with ethanol;lithium hydroxide at 35; for 1 h;
Steps:
1.6; 2.6
6) To 94.6g (4R) -5- [1,1'-biphenyl] -4-yl-4-[[tert-butoxycarbonyl] amino] -2-methyl-2-pentenoic acid ethyl esterAdd 473mL ethanolAnd 13.7g of lithium hydroxide, stirred at 35 for 1h,After the reaction, the crystals were concentrated to obtain 61.4g(R, E) -5-([1,1'-biphenyl] -4-yl) -4-((tert-butoxycarbonyl) amino) -2-methyl-2-pentenoic acid;(70% yield);
References:
NANJING HONGSHAN BIOTECHNOLOGY CO LTD;Nanjing Hongshan Biological Technology Co., Ltd.;WU FAHAO;Wu Fahao;LI GANG;Li Gang;GAO YANGZHE;Gao Yangzhe CN108299226, 2018, A Location in patent:Paragraph 0016; 0027; 0033; 0037; 0043
![LCZ696 InteMediate](/CAS/20150408/GIF/1426129-50-1.gif)
1426129-50-1
265 suppliers
$5.00/250mg
![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](/CAS/20150408/GIF/1012341-48-8.gif)
1012341-48-8
205 suppliers
$9.00/1g
![Boc-4-bromo-D-phenylalanine methyl ester](/CAS/20180629/GIF/1213855-60-7.gif)
1213855-60-7
22 suppliers
$119.17/0.5g
![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](/CAS/20150408/GIF/1012341-48-8.gif)
1012341-48-8
205 suppliers
$9.00/1g
![METHYL-N-TERT-BUTYLOXYCARBONYL-AMINO-4,4'-BIPHENYL-R-ALANINE](/CAS/GIF/149818-98-4.gif)
149818-98-4
26 suppliers
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![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](/CAS/20150408/GIF/1012341-48-8.gif)
1012341-48-8
205 suppliers
$9.00/1g
![((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester](/CAS/20150408/GIF/149709-58-0.gif)
149709-58-0
45 suppliers
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![(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid](/CAS/20150408/GIF/1012341-48-8.gif)
1012341-48-8
205 suppliers
$9.00/1g