Boronic acid, B-[2-(difluoroMethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]- synthesis

5synthesis methods

Product Name:Boronic acid, B-[2-(difluoroMethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-
CAS Number:1014613-45-6
Molecular formula:C14H11BF2N2O4S
Molecular Weight:352.12

4-BROMO-1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDINE

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Boronic acid, B-[2-(difluoroMethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-

1014613-45-6
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.67 h / 20 °C
1.2: -30 - 20 °C
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexanes / 4.17 h / -78 - 20 °C
4.1: hydrogenchloride; water / tetrahydrofuran; hexanes / 0.17 h / -78 °C

References:

WO2008/145688,2008,A2

942920-59-4 Synthesis