1-[4-[(3-aminophenyl)methyl]-1-piperazinyl]ethanone synthesis

3synthesis methods

Product Name:1-[4-[(3-aminophenyl)methyl]-1-piperazinyl]ethanone
CAS Number:1016696-88-0
Molecular formula:C13H19N3O
Molecular Weight:233.31

Ethanone, 1-[4-[(3-nitrophenyl)methyl]-1-piperazinyl]-

314061-27-3
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1-[4-[(3-aminophenyl)methyl]-1-piperazinyl]ethanone

1016696-88-0
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Yield:1016696-88-0 0.9 g

Reaction Conditions:

with hydrogenchloride;iron in ethanol;water at 90;

Steps:

General procedure: Step 2 A mixture of 4-(3-nitrobenzyl) morpholine (5.0 g, 22.4 mmol,1.0 eq), iron powder (6.3 g, 112.1 mmol, 5.0 eq) and 2 N HCl (1 mL) inEtOH (14 mL) and water (6 mL) was heated at 90 C for 2 h andconcentrated under reduced pressure. The mixture was filtered withdiatomaceous earth and extracted with EtOAc (3 × 20 mL). The combinedorganic extracts were washed with brine, dried over anhydrousNa2SO4 and concentrated under reduced pressure to give compound 13as a yellow solid (3.6 g, yield: 82%).

References:

Song, Shukai;Tang, Haotian;Ran, Ting;Fang, Feng;Tong, Linjiang;Chen, Hongming;Xie, Hua;Lu, Xiaoyun [European Journal of Medicinal Chemistry,2023,vol. 247,art. no. 115034]

3958-57-4 Synthesis

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References

13889-98-0 Synthesis

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