(12Z)-Labda-8(17),12,14-triene-19-oic acid methyl ester synthesis

1synthesis methods

Product Name:(12Z)-Labda-8(17),12,14-triene-19-oic acid methyl ester
CAS Number:10178-35-5
Molecular formula:C21H32O2
Molecular Weight:316.48

(1S,8aα)-1,4aβ-Dimethyl-5β-(3-methyl-2,4-pentadienyl)-6-methylenedecalin-1β-carboxylic acid methyl ester

1235-39-8
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(12E)-Labda-8(17),12,14-triene-19-oic acid methyl ester

15798-13-7
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(12Z)-Labda-8(17),12,14-triene-19-oic acid methyl ester

10178-35-5
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Yield:15798-13-7 74%

Reaction Conditions:

with iodine in cyclohexane at 90; for 2 h;Inert atmosphere;Overall yield = 300 mg;

References:

MacK, Daniel J.;Njardarson, Jon T. [Angewandte Chemie - International Edition,2013,vol. 52,# 5,p. 1543 - 1547][Angew. Chem.,2013,vol. 125,# 5,p. 1583 - 1587,5] Location in patent:supporting information