1-(4-METHOXY-PHENYL)-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE synthesis

1synthesis methods

Product Name:1-(4-METHOXY-PHENYL)-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE
CAS Number:1020717-93-4
Molecular formula:C12H12F3NO2
Molecular Weight:259.22

METHYL 5,5,5-TRIFLUORO-4-(4-METHOXYPHENYLAMINO)PENTANOATE

937371-63-6
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1-(4-METHOXY-PHENYL)-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE

1020717-93-4
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inquiry

Yield:1020717-93-4 92%

Reaction Conditions:

with sodium hydride in tetrahydrofuran at 20; for 2 h;Inert atmosphere;

References:

Wan, Wen;Hou, Jie;Jiang, Haizhen;Yuan, Zongqian;Goubin, Ma.;Zhao, Gang;Hao, Jian [European Journal of Organic Chemistry,2010,# 9,p. 1778 - 1786] Location in patent:experimental part