6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine synthesis

3synthesis methods

Product Name:6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine
CAS Number:1022931-56-1
Molecular formula:C8H10F3N3
Molecular Weight:205.18

TERT-BUTYL 3-(TRIFLUOROMETHYL)-1,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDINE-6-CARBOXYLATE

733757-89-6
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6-methyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

1022931-56-1
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Yield:1022931-56-1 71%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 58; for 17 h;Inert atmosphere;

References:

Ward, Simon E.;Harries, Mark;Aldegheri, Laura;Austin, Nigel E.;Ballantine, Stuart;Ballini, Elisa;Bradley, Daniel M.;Bax, Benjamin D.;Clarke, Brian P.;Harris, Andrew J.;Harrison, Stephen A.;Melarange, Rosemary A.;Mookherjee, Claudette;Mosley, Julie;Dal Negro, Gianni;Oliosi, Beatrice;Smith, Kathrine J.;Thewlis, Kevin M.;Woollard, Patrick M.;Yusaf, Shahnaz P. [Journal of Medicinal Chemistry,2011,vol. 54,# 1,p. 78 - 94] Location in patent:experimental part

647863-25-0 Synthesis

tert-Butyl 3-oxo-4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

647863-25-0
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1022931-56-1
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References

98977-36-7 Synthesis

98977-36-7
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1022931-56-1
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References