4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide synthesis
- Product Name:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-3-en-1-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl)[1,1'-biphenyl]-2-sulfonamide
- CAS Number:1026355-73-6
- Molecular formula:C34H44N4O6S
- Molecular Weight:636.8
138402-05-8
84 suppliers
$13.00/1g
1026273-26-6
6 suppliers
inquiry
1026355-73-6
9 suppliers
inquiry
Yield:1026355-73-6 32 g
Reaction Conditions:
Stage #1: 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4onewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 0.333333 h;
Stage #2: 4'-(bromomethyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide in N,N-dimethyl-formamide;mineral oil at 0 - 20;
Steps:
3.F Step F. 4’-[(2-Butyl-4-oxo-1,3-diazaspiro[4. 4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2’-(ethoxymethyl)-N-(methoxymethyl) [1,1’-biphenyl]-2-sulfonamide
Step F.
4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4. 4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide
4'-(Bromomethyl)-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N-(methoxymethyl) [1,1'-biphenyl]-2-sulfonamide] (entire sample) was used to alkylate 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one according to General Method 1.
The crude residue was chromatographed on silica gel using hexanes/ethyl acetate/triethylamine as eluant to provide 4'-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl-N-](4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-N- (methoxymethyl) [1,1'-biphenyl]-2-sulfonamide (32 g, 53% from Step B) as a slightly yellow oil.
References:
EP2732818,2017,B1 Location in patent:Paragraph 0174; 0149
41963-20-6
179 suppliers
$15.00/1g
1026355-73-6
9 suppliers
inquiry
190197-86-5
43 suppliers
inquiry
1026355-73-6
9 suppliers
inquiry
837408-71-6
36 suppliers
inquiry
1026355-73-6
9 suppliers
inquiry
837408-81-8
13 suppliers
inquiry
1026355-73-6
9 suppliers
inquiry