Carbamic acid, N-[1-[(4-fluorophenyl)sulfonyl]-4-piperidinyl]-, 1,1-dimethylethyl ester synthesis

Yield:1027785-44-9 98%

Reaction Conditions:

with triethylamine in tetrahydrofuran at 20; for 2 h;

Steps:

11.E

To a solution of tert-butyl piperidin-4-ylcarbamate (200 mg, 1 mmol) in tetrahydrofuran (5 mL) were added 4-fluorobenzenesulfonyl chloride (195 mg, 1 mmol), triethylamine (0.2 mL) and the mixture was stirred at RT. After 2 h, the volatiles were removed in vacuo and the water was added to the residue. The solid formed was filtered, washed successively with water, IN HCl, and water to afford tert-butyl l-(4-fluorophenylsulfonyl)piperidin-4-ylcarbamate( 350 mg, 98%) as a solid. LC/MS; (M+H)⁺ = 359.

References:

WO2008/60907,2008,A2 Location in patent:Page/Page column 40