Cyclohexaneacetic acid, 4-[4-(cyanoMethyl)phenyl]-, ethyl ester, trans- synthesis

7synthesis methods

Product Name:Cyclohexaneacetic acid, 4-[4-(cyanoMethyl)phenyl]-, ethyl ester, trans-
CAS Number:1031336-85-2
Molecular formula:C18H23NO2
Molecular Weight:285.38

773837-37-9 Synthesis

773837-37-9
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Cyclohexaneacetic acid, 4-[4-(broMoMethyl)phenyl]-, ethyl ester, trans-

1359943-47-7
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Cyclohexaneacetic acid, 4-[4-(cyanoMethyl)phenyl]-, ethyl ester, trans-

1031336-85-2
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Yield:1031336-85-2 67%

Reaction Conditions:

in water;acetonitrile at 40 - 50; for 6.25 h;Inert atmosphere;

References:

Yeh, Vince S. C.;Beno, David W. A.;Brodjian, Sevan;Brune, Michael E.;Cullen, Steven C.;Dayton, Brian D.;Dhaon, Madhup K.;Falls, Hugh D.;Gao, Ju;Grihalde, Nelson;Hajduk, Philip;Hansen, T. Matthew;Judd, Andrew S.;King, Andrew J.;Klix, Russel C.;Larson, Kelly J.;Lau, Yau Y.;Marsh, Kennan C.;Mittelstadt, Scott W.;Plata, Dan;Rozema, Michael J.;Segreti, Jason A.;Stoner, Eric J.;Voorbach, Martin J.;Wang, Xiaojun;Xin, Xili;Zhao, Gang;Collins, Christine A.;Cox, Bryan F.;Reilly, Regina M.;Kym, Philip R.;Souers, Andrew J. [Journal of Medicinal Chemistry,2012,vol. 55,# 4,p. 1751 - 1757] Location in patent:experimental part

1031336-68-1 Synthesis

Cyclohexaneacetic acid, 4-[4-(chlorocarbonyl)phenyl]-, ethyl ester, trans-

1031336-68-1
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1031336-85-2
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References

1031336-84-1 Synthesis

Cyclohexaneacetic acid, 4-[4-(hydroxyMethyl)phenyl]-, ethyl ester, trans-

1031336-84-1
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1031336-85-2
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References

4894-75-1
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$6.00/5g

1031336-85-2
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References

Cyclohexaneacetic acid, 4-phenyl-, ethyl ester, trans-

1031336-66-9
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1031336-85-2
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References