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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide

2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol synthesis

4synthesis methods
Acetone

67-64-1
6 suppliers
$19.10/10ml

2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine

16234-15-4
98 suppliers
$25.00/100mg

2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol

1033743-25-7
12 suppliers
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Yield:1033743-25-7 83.5%

Reaction Conditions:

Stage #1: 2-chloro-4-morpholinothieno[3,2-d]pyrimidinewith n-butyllithium in tetrahydrofuran;hexane at -78 - -60;
Stage #2: acetone in tetrahydrofuran;hexane at -78 - -70;

References:

Sutherlin, Daniel P.;Sampath, Deepak;Berry, Megan;Castanedo, Georgette;Chang, Zhigang;Chuckowree, Irina;Dotson, Jenna;Folkes, Adrian;Friedman, Lori;Goldsmith, Richard;Heffron, Tim;Lee, Leslie;Lesnick, John;Lewis, Cristina;Mathieu, Simon;Nonomiya, Jim;Olivero, Alan;Pang, Jodie;Prior, Wei Wei;Salphati, Laurent;Sideris, Steve;Tian, Qingping;Tsui, Vickie;Wan, Nan Chi;Wang, Shumei;Wiesmann, Christian;Wong, Susan;Zhu, Bing-Yan [Journal of Medicinal Chemistry,2010,vol. 53,# 3,p. 1086 - 1097] Location in patent:experimental part

16234-14-3 Synthesis
2,4-Dichlorothieno[3,2-d]pyrimidine

16234-14-3
287 suppliers
$3.00/1g

2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol

1033743-25-7
12 suppliers
inquiry

References
22288-78-4 Synthesis
Methyl 3-amino-2-thiophenecarboxylate

22288-78-4
385 suppliers
$11.00/5g

2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol

1033743-25-7
12 suppliers
inquiry

References
1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

16233-51-5
165 suppliers
$6.00/250mg

2-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)propan-2-ol

1033743-25-7
12 suppliers
inquiry

References