8-acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one synthesis
- Product Name:8-acetyl-5-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one
- CAS Number:1035229-32-3
- Molecular formula:C17H15NO4
- Molecular Weight:297.31
871101-87-0
24 suppliers
$327.00/1g
79-04-9
350 suppliers
$12.00/5g
1035229-32-3
34 suppliers
$35.00/100mg
Yield:1035229-32-3 95%
Reaction Conditions:
Stage #1: 1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone;chloroacetyl chloridewith sodium hydrogencarbonate in N,N-dimethyl-formamide; for 2 h;Inert atmosphere;
Stage #2: with caesium carbonate in N,N-dimethyl-formamide at 100; for 20 h;Inert atmosphere;
References:
Sweis, Ramzi F.;Wang, Zhi;Algire, Mikkel;Arrowsmith, Cheryl H.;Brown, Peter J.;Chiang, Gary G.;Guo, Jun;Jakob, Clarissa G.;Kennedy, Steven;Li, Fengling;Maag, David;Shaw, Bailin;Soni, Nirupama B.;Vedadi, Masoud;Pappano, William N. [ACS Medicinal Chemistry Letters,2015,vol. 6,# 6,p. 695 - 700] Location in patent:supporting information
601-89-8
232 suppliers
$14.00/5g
1035229-32-3
34 suppliers
$35.00/100mg
89684-58-2
22 suppliers
$209.03/1g
1035229-32-3
34 suppliers
$35.00/100mg
1035229-31-2
24 suppliers
$130.00/100mg
1035229-32-3
34 suppliers
$35.00/100mg
871101-87-0
24 suppliers
$327.00/1g
1035229-32-3
34 suppliers
$35.00/100mg