ChemicalBook CAS DataBase List ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate

ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate synthesis

9synthesis methods

Product Name:ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate
CAS Number:1035404-19-3
Molecular formula:C18H18ClNO4
Molecular Weight:347.79

25563-04-6 Synthesis

25563-04-6
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ethyl 2-(2-(2-(4-chlorophenoxy)phenyl)-N-MethylacetaMido)acetate

1035404-19-3
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Yield:1035404-19-3 83.8%

Reaction Conditions:

with pivaloyl chloride;triethylamine in dichloromethane at 0 - 15;Reagent/catalyst;Temperature;

Steps:

1

30 ml of methylene chloride was added to a 100 ml three-necked flask, and 5.6 g of 2- (4-chlorophenoxy) phenylacetic acid was added as a starting material,Cooling to 0 ~ 5 ° C, dropping pivaloyl chloride / dichloromethane = 12.1g / 10ml, in another 250ml three bottles of sarcosine methyl ester hydrochloride 5.6g, cooling to 10 ° C below,Add triethylamine 4. lg stirring 30 minutes,A solution of mixed anhydride in dichloromethane (5.6 g / 20 ml) was slowly added dropwise,Control 15 ° C the following dropping; plus complete,The stirring was continued for 3 to 4 hours,Adding 50ml of purified water for 5 minutes, extracting and separating,The organic phase was extracted once more with 50 ml of purified water,The organic phase was concentrated to constant weight,To give a brown or tan oil,I.e., 6.2 g of the intermediate compound of formula (I) in 83.8% yield.

References:

CN104098580,2016,B Location in patent:Paragraph 0029; 0033; 0034