ChemicalBook CAS DataBase List N-(1-Cyano-2-hydroxy-1-methylethyl)-4-[(trifluoromethyl)thio]-benzamide

N-(1-Cyano-2-hydroxy-1-methylethyl)-4-[(trifluoromethyl)thio]-benzamide synthesis

1synthesis methods

Product Name:N-(1-Cyano-2-hydroxy-1-methylethyl)-4-[(trifluoromethyl)thio]-benzamide
CAS Number:1036762-89-6
Molecular formula:C12H11F3N2O2S
Molecular Weight:304.2881

Propanenitrile, 2-amino-3-hydroxy-2-methyl-

122556-12-1
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5030-59-1
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N-(1-Cyano-2-hydroxy-1-methylethyl)-4-[(trifluoromethyl)thio]-benzamide

1036762-89-6
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Yield:1036762-89-6 74%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 5 h;Schlenk technique;

References:

Hess, Jeannine;Patra, Malay;Rangasamy, Loganathan;Konatschnig, Sandro;Blacque, Olivier;Jabbar, Abdul;Mac, Patrick;Jorgensen, Erik M.;Gasser, Robin B.;Gasser, Gilles [Chemistry - A European Journal,2016,vol. 22,# 46,p. 16602 - 16612] Location in patent:supporting information