ChemicalBook CAS DataBase List ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate

ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate synthesis

4synthesis methods

Product Name:ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate
CAS Number:1038828-20-4
Molecular formula:C11H12N2O2
Molecular Weight:204.23

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2-Butenoic acid, 3-nitro-, ethyl ester, (2Z)-

52194-41-9
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ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate

1038828-20-4
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Yield:1038828-20-4 74%

Reaction Conditions:

with 1-hydrogeno-3-butylimidazolium tetrafluoroborate at 20; for 0.833333 h;Green chemistry;Reagent/catalyst;

Steps:

A mixtureof 2-aminopyridine 1a (1 mmol) and β-nitroacrylate 2a (1 mmol) in 5 mL ionic liquid[Hbim]BF₄ was stirred at roomtemperature for stipulated time (Table 1). The progress of the reaction was monitored by TLC. After the completionof the reaction, the reaction mixture was extracted with ether (3x15 mL). The combined organic layers were washedwith brine solution, and dried over Na₂SO_4.TheNa₂SO₄was filtered off and the solventwas removed under vacuum. The residue obtained was then purifiedby silica gel column chromatography (100-200 mesh) using ethyl acetate: hexane(5:95 to 20:80) as eluent to get corresponding products

References:

Babu, B. Madhu;Kumar, G. Santosh;Thakur, Pramod B.;Bangade, Vikas M.;Meshram [Tetrahedron Letters,2014,vol. 55,# 24,p. 3473 - 3477] Location in patent:supporting information

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57332-84-0 Synthesis