6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid synthesis

2synthesis methods

Product Name:6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
CAS Number:103994-99-6
Molecular formula:C16H8F3NO3
Molecular Weight:319.23

1-(p-fluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

108138-16-5
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6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

103994-99-6
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$165.00/10mg

Yield:103994-99-6 86%

Reaction Conditions:

with hydrogenchloride;acetic acid

Steps:

C.6 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester

6. 6,7-Difluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 6,7-Difluoro-1-(4-flurophenyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid ethyl ester (14.5 g, 42 mmol) was mixed with acetic acid (300 ml), treated with 1N hydrochloric acid (100 ml) and heated to 100° for 4 hours. The reaction mixture was cooled and filtered, and the precipitate washed with water and ethyl ether to provide the title product as a solid, m.p. 252°-256° (11.5 g, 36.0 mmol, 86% yield). ¹ H NMR (DMSO-d₆): 8.8 (s, 1H), 8.3 (dd, J=6, 7 Hz, 1H), 7.8 (m, 2H), 7.6 (m, 2H), 7.2 (dd, J=5, 8 Hz, 1H).

References:

US5037834,1991,A

Benzenepropanoic acid, 2,4,5-trifluoro-α-[[(4-fluorophenyl)amino]methylene]-β-oxo-, ethyl ester

108115-66-8
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103994-99-6
17 suppliers
$165.00/10mg

References