ChemicalBook CAS DataBase List N-(1,2,3,4-tetrahydroisoquinolin-6-yl)methanesulfonamide

N-(1,2,3,4-tetrahydroisoquinolin-6-yl)methanesulfonamide synthesis

3synthesis methods

Product Name:N-(1,2,3,4-tetrahydroisoquinolin-6-yl)methanesulfonamide
CAS Number:1044766-32-6
Molecular formula:C10H14N2O2S
Molecular Weight:226.2954

2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-[(methylsulfonyl)amino]-, 1,1-dimethylethyl ester

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N-(1,2,3,4-tetrahydroisoquinolin-6-yl)methanesulfonamide

1044766-32-6
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Yield:1044766-32-6 83%

Reaction Conditions:

with hydrogenchloride in dichloromethane;ethyl acetate at 20; for 8 h;

Steps:

22.4 Step 4) N- (1, 2, 3, 4-tetrahydroisoquinolin-6-yl) methanesulfonamide

Step 4) N- (1, 2, 3, 4-tetrahydroisoquinolin-6-yl) methanesulfonamide
To a solution of tert-butyl 6- (methylsulfonamido) -3, 4-dihydroisoquinoline-2 (1H) -carboxylate (326 mg, 1 mmol) in DCM (4 mL) was added an EtOAc solution of HCl (3 mL) . After the addition, the mixture was stirred at rt for 8 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in EtOAc. The mixture was filtered to give light yellow solid, which was adjusted with aqueous NaHCO₃to pH 8. The resulting mixture was filtered, and the filter cake washed with water and dried to give N- (1, 2, 3, 4-tetrahydroisoquinolin-6-yl) methanesulfonamide as a white solid (187 mg, 83) .[1076]MS (ESI, pos. ion) m/z: 227.1 [M+H]⁺.

References:

WO2015/197028,2015,A1 Location in patent:Paragraph 00133

6-AMINO-2-N-BOC-1,2,3,4-TETRAHYDRO-ISOQUINOLINE

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References

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References