2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- synthesis

13synthesis methods

Product Name:2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-
CAS Number:104587-51-1
Molecular formula:C5H11NO2
Molecular Weight:117.15

(3R,5S)-1-Benzyl-5-hydroxymethyl-pyrrolidin-3-ol

107746-25-8
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2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-

104587-51-1
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Yield:104587-51-1 96.5%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in ethanol under 7500.75 Torr; for 3 h;Autoclave;

Steps:

4
The TSSA 0200-C 1.5 ETH dissolved, was added into the autoclave, adding 0.015 g of palladium on carbon, introducing hydrogen to 1 MPa, and reacting for 3 hours, filtered to remove the palladium carbon, to obtain 0.82 g TSSA 0200-D, yield: 96.5%

References:

PUYER (NANTONG) Biopharma Co.,Ltd;WANG, LIN CN105837486, 2016, A Location in patent:Paragraph 0078

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