5-(1-(6-chloro-5-nitropyriMidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole synthesis

1synthesis methods

Product Name:5-(1-(6-chloro-5-nitropyriMidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole
CAS Number:1054579-82-6
Molecular formula:C14H17ClN6O3
Molecular Weight:352.78

4-(3-ISOPROPYL-1,2,4-OXADIAZOL-5-YL)PIPERIDINE HYDROCHLORIDE

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49845-33-2 Synthesis

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5-(1-(6-chloro-5-nitropyriMidin-4-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole

1054579-82-6
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Yield:1054579-82-6 72%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in dichloromethane at 0; for 2 h;

References:

Semple, Graeme;Fioravanti, Beatriz;Pereira, Guillherme;Calderon, Imelda;Uy, Jane;Choi, Karoline;Xiong, Yifeng;Ren, Albert;Morgan, Michael;Dave, Vibha;Thomsen, William;Unett, David J.;Xing, Charles;Bossie, Stuart;Carroll, Chris;Chu, Zhi-Liang;Grottick, Andrew J.;Hauser, Erin K.;Leonard, James;Jones, Robert M. [Journal of Medicinal Chemistry,2008,vol. 51,# 17,p. 5172 - 5175] Location in patent:supporting information; experimental part