ChemicalBook CAS DataBase List TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE synthesis

2synthesis methods

Product Name:TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
CAS Number:1056934-87-2
Molecular formula:C12H16ClN3O2
Molecular Weight:269.73

6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one

109229-22-3
89 suppliers
$129.00/1g

TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

1056934-87-2
89 suppliers
$184.00/250mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 18 h / 760.05 Torr / Inert atmosphere
2: triphenylphosphine; tetrachloromethane / 1,2-dichloro-ethane / 2.5 h / 70 °C

References:

Meredith, Erik L.;Mainolfi, Nello;Poor, Stephen;Qiu, Yubin;Miranda, Karl;Powers, James;Liu, Donglei;Ma, Fupeng;Solovay, Catherine;Rao, Chang;Johnson, Leland;Ji, Nan;Artman, Gerald;Hardegger, Leo;Hanks, Shawn;Shen, Siyuan;Woolfenden, Amber;Fassbender, Elizabeth;Sivak, Jeremy M.;Zhang, Yiqin;Long, Debby;Cepeda, Rosemarie;Liu, Fang;Hosagrahara, Vinayak P.;Lee, Wendy;Tarsa, Peter;Anderson, Karen;Elliott, Jason;Jaffee, Bruce [Journal of Medicinal Chemistry,2015,vol. 58,# 23,p. 9273 - 9285]

41276-30-6
101 suppliers
$61.96/1g

1056934-87-2
89 suppliers
$184.00/250mg

References

TERT-BUTYL 4-CHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE Related Search:

tert-butyl 4-chloro-5,6-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(8H)-carboxylate7(6H)-carboxylic acid