(2S)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid synthesis
- Product Name:(2S)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-3-phenylpropanoic acid
- CAS Number:105776-76-9
- Molecular formula:C17H15NO3
- Molecular Weight:281.31
Yield:105776-76-9 18%
Reaction Conditions:
in acetonitrile;Reflux;
Steps:
41 Preparation of (S)-2-(1-oxoisoindolin-2-yl)-3-phenylpropanoic acid
A mixture of 1.0 g (S)-2-amino-3-phenylpropanoic acid (6.1 mmol, 1.0 equiv) and 812 mg phthalaldehyde (6.1 mmol, 1.00 equiv) in 20 mL acetonitrile was refluxed overnight. The solid was filtered to give 300 mg (S)-2-(1-oxoisoindolin-2-yl)-3-phenylpropanoic acid as a white solid (18 % yield). MS (ESI+) m/z 282 [M+H]+
References:
WO2021/50992,2021,A1 Location in patent:Paragraph 00749-00750
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