3-(4-(2-chlorophenoxy)piperidine-1-carboxaMido)benzoic acid synthesis

Yield:1058702-87-6 87%

Reaction Conditions:

with sodium hydroxide in tetrahydrofuran;methanol at 20; for 16 h;

References:

Xin, Zhili;Zhao, Hongyu;Serby, Michael D.;Liu, Bo;Liu, Mei;Szczepankiewicz, Bruce G.;Nelson, Lissa T.J.;Smith, Harriet T.;Suhar, Tom S.;Janis, Rich S.;Cao, Ning;Camp, Heidi S.;Collins, Christine A.;Sham, Hing L.;Surowy, Teresa K.;Liu, Gang [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 15,p. 4298 - 4302] Location in patent:supporting information; experimental part