![](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride synthesis
- Product Name:(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- CAS Number:1062580-52-2
- Molecular formula:C14H23ClN2
- Molecular Weight:254.8
![(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine](/CAS/GIF/477600-70-7.gif)
477600-70-7
219 suppliers
$49.00/1g
![(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
1062580-52-2
325 suppliers
$48.00/1g
Yield:1062580-52-2 94%
Reaction Conditions:
with hydrogenchloride in ethanol; pH=3 - 4 at 0 - 5;
Steps:
1; 2; 3
Preparation of (3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine dihydrochloride: Intermediate TF-3 (16.2 g, in a reaction flask) 0.07 mol) was placed in 80 mL of ethanol, stirred to dissolve, and then 10 M hydrochloric acid in ethanol (56 mL, 0.26 mol, 8.0 eq) was added.The pH of the reaction solution was controlled to be between 3-4, and the temperature was lowered to 0-5 ° C, stirred and crystallized, suction filtered, and dried under reduced pressure to obtain 16 g of crude product. The crude product was placed in 90 mL of isopropanol, heated to reflux to dissolve, stirred for 1 h, cooled to 0-5 ° C for crystallization, suction filtered, and dried under reduced pressure to give 15.2 g (3R, 4R)-N,4- Dimethyl-1-(phenylmethyl)-3-piperidinamine dihydrochloride product, yield 94%, purity 99.5%.
References:
Nantong Changyou Pharmaceutical Technology Co., Ltd.;Li Zebiao;Ding Haiming;Zhang Lei;Guo Haifeng;Ma Tiantian;Yan Jun CN108976164, 2018, A Location in patent:Paragraph 0012; 0015; 0017; 0020; 0022; 0025
![1-benzyl-4-methylpiperidin-3-one](/CAS2/GIF/32018-96-5.gif)
32018-96-5
122 suppliers
$60.00/1 g
![Methylamine](/CAS/GIF/74-89-5.gif)
74-89-5
7 suppliers
$13.44/25ML
![(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
1062580-52-2
325 suppliers
$48.00/1g
![1-benzyl-4-methylpiperidin-3-one](/CAS2/GIF/32018-96-5.gif)
32018-96-5
122 suppliers
$60.00/1 g
![(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
1062580-52-2
325 suppliers
$48.00/1g
![(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester](/CAS/20150408/GIF/923036-28-6.gif)
923036-28-6
13 suppliers
inquiry
![(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
1062580-52-2
325 suppliers
$48.00/1g
![3-Amino-4-methylpyridine](/CAS/GIF/3430-27-1.gif)
3430-27-1
456 suppliers
$13.43/1gm:
![(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride](/StructureFile/ChemBookStructure22/GIF/CB21011155.gif)
1062580-52-2
325 suppliers
$48.00/1g