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2-(Bromomethyl)-3-(2-chlorophenyl)-5,6-difluoroquinoxaline synthesis

2synthesis methods
1-(2-Chlorophenyl)propane-1,2-dione

64497-33-2
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3-(Bromomethyl)-2-(2-chlorophenyl)-5,6-difluoroquinoxaline

1065481-84-6
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2-(Bromomethyl)-3-(2-chlorophenyl)-5,6-difluoroquinoxaline

1065481-83-5
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: bromine; acetic acid / chloroform / 12 - 17 h / 60 °C
2: ethyl acetate / 6 h / 20 °C

References:

AMGEN INC. WO2008/118468, 2008, A1