ChemicalBook CAS DataBase List 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine synthesis

2synthesis methods

Product Name:4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine
CAS Number:1072027-36-1
Molecular formula:C15H20BrN5O2
Molecular Weight:382.26

22276-95-5 Synthesis

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

22276-95-5
193 suppliers
$8.00/1g

57260-71-6 Synthesis

57260-71-6
736 suppliers
$5.00/5g

4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

1072027-36-1
28 suppliers
$17.00/250mg

Yield: 78.5%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in 1,4-dioxane at 80; for 2 h;Microwave irradiation;

Steps:

1.2 4-(4-Boc-1-piperazine)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine: Preparation of (Intermediate 3)
Intermediate 2 (5 mmol),1-tert-butoxycarbonylpiperazine (6 mmol) and DIEA (7.5 mmol) were dissolved in 5 ml of dioxane, and microwaved at 80 °C for 2 h. The solvent was evaporated under reduced pressure, and the mixture was evaporated, evaporated, evaporated, evaporated, evaporated, Recrystallization gave Intermediate 3. White solid, the yield is 78.5%.

References:

Shandong University;Zhao Guisen;Yu Shengping;Liu Yang;Wang Luhua;Guo Kaiwen;Hou Xianxin CN108997351, 2018, A Location in patent:Paragraph 0075; 0112; 0151; 0152

3680-69-1 Synthesis

3680-69-1
805 suppliers
$6.00/1g

1072027-36-1
28 suppliers
$17.00/250mg

References