![](/CAS/20180703/GIF/1073067-97-6.gif)
ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate synthesis
- Product Name:ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate
- CAS Number:1073067-97-6
- Molecular formula:C14H16BrNO3
- Molecular Weight:326.19
![2-Bromoaniline](/CAS/20180906/GIF/615-36-1.gif)
615-36-1
406 suppliers
$10.00/5g
![ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate](/CAS/20180703/GIF/1073067-97-6.gif)
1073067-97-6
19 suppliers
$111.00/100mg
Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 0 °C
1.2: 2 h / 0 - 19 °C
1.3: Reflux
2.1: hydrogenchloride; acetic acid / 3 h / 80 °C
3.1: borane-THF / tetrahydrofuran / 16 h / -15 °C / Inert atmosphere
References:
Bruncko, Milan;Wang, Le;Sheppard, George S.;Phillips, Darren C.;Tahir, Stephen K.;Xue, John;Erickson, Scott;Fidanze, Steve;Fry, Elizabeth;Hasvold, Lisa;Jenkins, Gary J.;Jin, Sha;Judge, Russell A.;Kovar, Peter J.;Madar, David;Nimmer, Paul;Park, Chang;Petros, Andrew M.;Rosenberg, Saul H.;Smith, Morey L.;Song, Xiaohong;Sun, Chaohong;Tao, Zhi-Fu;Wang, Xilu;Xiao, Yu;Zhang, Haichao;Tse, Chris;Leverson, Joel D.;Elmore, Steven W.;Souers, Andrew J. [Journal of Medicinal Chemistry,2015,vol. 58,# 5,p. 2180 - 2194]
![ethyl 7-bromo-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate](/CAS/20180629/GIF/1073493-75-0.gif)
1073493-75-0
16 suppliers
$45.00/10mg
![ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate](/CAS/20180703/GIF/1073067-97-6.gif)
1073067-97-6
19 suppliers
$111.00/100mg
![1H-Indole-3-propanoic acid, 7-bromo-2-(ethoxycarbonyl)-](/CAS/20210305/GIF/1073067-96-5.gif)
1073067-96-5
0 suppliers
inquiry
![ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate](/CAS/20180703/GIF/1073067-97-6.gif)
1073067-97-6
19 suppliers
$111.00/100mg
![Ethyl 2-oxocyclopentanecarboxylate](/CAS/GIF/611-10-9.gif)
611-10-9
402 suppliers
$10.00/5g
![ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate](/CAS/20180703/GIF/1073067-97-6.gif)
1073067-97-6
19 suppliers
$111.00/100mg