ChemicalBook CAS DataBase List 4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER

4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER synthesis

2synthesis methods

Product Name:4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER
CAS Number:1073354-18-3
Molecular formula:C19H31BN2O2
Molecular Weight:330.27

73183-34-3
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$6.00/5g

844431-60-3 Synthesis

1-(4-BROMO-PHENYL)-4-ISOPROPYL-PIPERAZINE

844431-60-3
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$45.00/10mg

4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER

1073354-18-3
40 suppliers
$55.00/50mg

Yield:1073354-18-3 4.2 g

Reaction Conditions:

with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂;potassium acetate in toluene at 110;Inert atmosphere;

Steps:

368.4 Step 4: 1-isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)phenyl) piperazine

[01003] 1-(4-Bromophenyl)-4-isopropylpiperazine (4.3 g, 15.19 mmol) was dissolved in degassed toluene (43 mL). To this, potassium acetate (5.88 g, 60 mmol), bis(pinacolato)diboron (6.5 g, 25.67 mmol) and Pd(dppf)CI2.DCM complex (1.22 g, 1.44 mmol) were added under nitrogen atmosphere and the reaction mass was stirred at 110 °C for 4 h. The volatiles were removed under reduced pressure to give crude product (4.2 g) as a black solid which was used as such in next step without further purification. LCMS: [M+H] + = 331.46.

References:

WO2022/226668,2022,A1 Location in patent:Paragraph 01000; 01003

66698-28-0 Synthesis

66698-28-0
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$10.00/250mg

1073354-18-3
40 suppliers
$55.00/50mg

References

4-(4-ISOPROPYLPIPERIZINYL)PHENYLBORONIC ACID, PINACOL ESTER Related Search:

5-Methylthiophene-3-boronic acid 2-FLUORO-3-METHOXYPHENYLBORONIC ACID 1-METHYL-4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PIPERAZINE 1-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-piperazine 4-(N-METHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER