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ChemicalBook CAS DataBase List 3-(4-HYDROXYMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER

3-(4-HYDROXYMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere; Sealed tube
2: hydrogen; palladium 10% on activated carbon / ethanol / 2 h / 2660.18 Torr

References:

JANSSEN PHARMACEUTICA NV;KUO, Gee-Hong;PLAYER, Mark R.;YANG, Shyh-Ming;ZHANG, Yue-Mie;HUANG, Hui WO2016/57731, 2016, A1