1-(4-aMino-5-Methoxy-2-Methylphenyl)-N,N-diMethylpiperidin-4-aMine synthesis

Yield:1089279-91-3 92.6%

Reaction Conditions:

with 10% Pd/C;hydrogen in methanol; for 6 h;

Steps:

9.4 Step (4) 1- (4-Amino-3-methoxyphenyl) -N, N-dimethylpiperidin-4-amine (7-6)

Weigh 4.09 g of compound 29 in a reaction flask,Add 40mL methanol dissolved,0.4 g of 10% Pd / C (10% by weight of II-2)Hydrogenation reduction; TLC monitoring, about 6h,Reaction is complete, stop reaction;Filter, a small amount of methanol rinse,Distillation under reduced pressure was 3.38 g of a brown solid 7-6,The yield was 92.60%.

References:

CN106905245,2017,A Location in patent:Paragraph 0249; 0259; 0260; 0261; 0262