6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]- synthesis
- Product Name:6H-Purin-6-one, 1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(triphenylMethoxy)ethoxy]Methyl]-2-[(triphenylMethyl)aMino]-
- CAS Number:109082-85-1
- Molecular formula:C47H41N5O4
- Molecular Weight:739.86
82410-32-0
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Yield:-
Reaction Conditions:
with dmap;triethanolamine in N-methyl-acetamide;
Steps:
1 Preparation of N-trityl-2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-trityloxy-propan-1-ol
EXAMPLE 1 Preparation of N-trityl-2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-3-trityloxy-propan-1-ol 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (ganciclovir) was bis-tritylated at the N and O functionalities as follows: to a slurry of 4.1 kg ganciclovir, 9.5 g DMAP, and 8.65 kg TEA in dimethylformamide (38.3 kg) at 50° C. was added a solution of 11.9 kg trityl-chloride in 38.2 kg dimethylformamide over 25 minutes.
References:
US5756736,1998,A