Carbamic acid, N-(2-fluoro-5-hydroxyphenyl)-, 1,1-dimethylethyl ester synthesis
- Product Name:Carbamic acid, N-(2-fluoro-5-hydroxyphenyl)-, 1,1-dimethylethyl ester
- CAS Number:1092394-26-7
- Molecular formula:C11H14FNO3
- Molecular Weight:227.23
62257-16-3
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Yield:1092394-26-7 61%
Reaction Conditions:
with indium(III) trichloride at 40; for 4 h;
Steps:
Step 2. Synthesis of compound (234)
3-amino-4-fluoro-phenol 233 (2.18g, 17.1 mmol, 1 .Oeq) was added to a molten mixture of di-tert-butyl dicarbonate (3.74g, 17.1 mmol, 1 .0eq) and indium (III) chloride (38mg, 0.1 7mmol, 0.01 eq). The reaction mixture was stirred at 40°C for 4 hours. After cooling down, flash chromatography on silica gel was performed using cyclohexane and ethyl acetate to afford expected compound 234 (Yield: 61 %, 2.38g) as off-white solid
References:
WO2021/13712,2021,A1 Location in patent:Page/Page column 152
2105-96-6
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1092394-26-7
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24424-99-5
824 suppliers
$13.50/25G
1092394-26-7
3 suppliers
inquiry