ChemicalBook CAS DataBase List (2S3R)-Methyl 3-aMino-2-(tert-butoxycarbonyl)butanoate

(2S3R)-Methyl 3-aMino-2-(tert-butoxycarbonyl)butanoate synthesis

2synthesis methods

Product Name:(2S3R)-Methyl 3-aMino-2-(tert-butoxycarbonyl)butanoate
CAS Number:1093190-13-6
Molecular formula:C10H20N2O4
Molecular Weight:232.28

methyl (2S,3S)-3-hydroxy-2-[(triphenylmethyl)amino]butanoate

728877-98-3
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(2S3R)-Methyl 3-aMino-2-(tert-butoxycarbonyl)butanoate

1093190-13-6
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: diethylazodicarboxylate; triphenylphosphine; diphenyl phosphoryl azide / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere
2: hydrogenchloride / tetrahydrofuran; diethyl ether / 5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / 20 °C
4: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C

References:

Piizzi, Grazia;Parker, David T.;Peng, Yunshan;Dobler, Markus;Patnaik, Anup;Wattanasin, Som;Liu, Eugene;Lenoir, Francois;Nunez, Jill;Kerrigan, John;McKenney, David;Osborne, Colin;Yu, Donghui;Lanieri, Leanne;Bojkovic, Jade;Dzink-Fox, Joann;Lilly, Maria-Dawn;Sprague, Elizabeth R.;Lu, Yipin;Wang, Hongming;Ranjitkar, Srijan;Xie, Lili;Wang, Bing;Glick, Meir;Hamann, Lawrence G.;Tommasi, Ruben;Yang, Xia;Dean, Charles R. [Journal of Medicinal Chemistry,2017,vol. 60,# 12,p. 5002 - 5014]

24424-99-5 Synthesis

24424-99-5
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1093190-13-6
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References