ChemicalBook CAS DataBase List 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride

2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride synthesis

4synthesis methods

Product Name:2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
CAS Number:1094042-01-9
Molecular formula:C23H27N3O4
Molecular Weight:409.48

60899-34-5 Synthesis

2,3-dihydro-1-oxo-1H-indene-4-carbonitrile

60899-34-5
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2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride

1094042-01-9
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$39.00/1mg

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; ethanol; silica gel / 0 - 20 °C
2.1: hydroxylamine hydrochloride; potassium carbonate / ethanol / 16 h / Reflux
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
3.2: 1.08 h / 20 - 130 °C / Microwave irradiation
4.1: pyridine; thionyl chloride / dichloromethane / 0 - 20 °C
4.2: 48 h / 50 °C

References:

THE SCRIPPS RESEARCH INSTITUTE WO2009/151529, 2009, A1

FullText

1H-Inden-1-ol, 4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-

1093827-52-1
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141-43-5 Synthesis

141-43-5
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1094042-01-9
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References

1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile

125114-76-3
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1094042-01-9
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References

N,1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide

1093827-51-0
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1094042-01-9
76 suppliers
$39.00/1mg

References