1-(7-chloro-6-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone synthesis

3synthesis methods

Product Name:1-(7-chloro-6-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone
CAS Number:1097920-65-4
Molecular formula:C11H8ClF3N2O3
Molecular Weight:308.64

1-(7-chloro-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone

1097920-64-3
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1-(7-chloro-6-nitro-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone

1097920-65-4
14 suppliers
$90.00/50mg

Yield:1097920-65-4 60 %

Reaction Conditions:

with sulfuric acid;nitric acid in water at -10;

Steps:

Step 3: Synthesis of 1-(7-Chloro-6-nitro-3, 4-dihydroisoquinolin-2(lH)-yl)-2, 2, 2-trifluoroethanone

To a solution of 1-(7-chloro-3,4-dihydroisoquinolin-2(lH)-yl)-2, 2, 2-trifluoroethanone (50 g, 190 mmol) in cone, sulfuric acid (500 mL) was added nitric acid (23.9 g, 379 mmol) at -10 °C and stirring was continued for 4 h. The reaction mixture was poured into ice cold water and extracted with ethyl acetate. The combined organic phases were dried over anhydrous Na₂SO₄, filtered and concentrated. The crude compound was purified by flash column chromatography (SiO₂, 100-200 mesh, 10% ethyl acetate in pet ether) to afford a light yellow solid (35 g, 60%). LCMS (m/z) = 307.0 [M-H]⁺

References:

WO2022/214869,2022,A2 Location in patent:Paragraph 000159

156-41-2 Synthesis

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1097920-65-4
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1097920-65-4
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