N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide synthesis

5synthesis methods

Product Name:N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
CAS Number:110139-15-6
Molecular formula:C12H13NO2
Molecular Weight:203.24

1-ACETAMIDO-5,6,7,8-TETRAHYDRONAPHTHALENE

6272-18-0
22 suppliers
$45.00/50mg

N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide

110139-15-6
19 suppliers
$385.00/1g

Yield:110139-15-6 76%

Reaction Conditions:

with potassium permanganate;lithium hydroxide monohydrate;magnesium(II) sulfate in propan-2-one at 20;

Steps:

81.2 Step 2:

C096-1 (8.0 g, 42.27 mmol) was dissolved in acetone (300 mL), 15% magnesium sulfate (899 mg, 7.47 mmol) aqueous solution (5 mL) was added at room temperature, and potassium permanganate solid (2.0 g, 12.66 mmol) was added in batches mmol), the addition was completed in about half an hour, and the mixture was stirred at room temperature overnight. TLC detected that the reaction of the raw materials was complete. The reaction solution was added with ethyl acetate, vigorously stirred, filtered through a pad of celite, washed, the filtrate was separated, washed with water, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and the crude product was purified by silica gel column chromatography to obtain a yellow solid C096-2 ( 6.5 g, 76% yield).

References:

WO2022/17531,2022,A1 Location in patent:Page/Page column 103