L-3-methyl-2-(pyridine-4-yl-methylamino)butanoicacid synthesis
1synthesis methods
- Product Name:L-3-methyl-2-(pyridine-4-yl-methylamino)butanoicacid
- CAS Number:1105060-26-1
- Molecular formula:C11H16N2O2
- Molecular Weight:208.26
Yield:1105060-26-1 70%
Reaction Conditions:
Stage #1: pyridine-4-carbaldehyde;L-valinewith sodium carbonate in methanol;water; for 3 h;Cooling with ice;
Stage #2: with sodium tetrahydroborate in methanol;water; for 12 h;Cooling with ice;
References:
Saha, Subhadeep;Das, Gobinda;Thote, Jayshri;Banerjee, Rahul [Journal of the American Chemical Society,2014,vol. 136,# 42,p. 14845 - 14851] Location in patent:supporting information