N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide synthesis
- Product Name:N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-4-(trifluoroMethyl)-BenzenesulfonaMide
- CAS Number:1105576-13-3
- Molecular formula:C21H19F3N2O2S
- Molecular Weight:420.45
2991-42-6
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1105576-13-3
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Yield:1105576-13-3 82%
Reaction Conditions:
in dichloromethane;1,2-dichloro-ethane at 0; for 4 h;
Steps:
20.1
(1)According to the method of step (1) in Preparation 1,the difference is,Using p-trifluoromethylphenylsulfonyl chloride (20 mmol, available from Kling 247070)Instead of p-methylphenylsulfonyl chloride and reacted at 0 ° C for 4 h,Thus, 16.4 mmol of the chiral diamine represented by the formula (R, R) - (3-1-1-6) was obtained in a yield of 82%
References:
CN107286089,2017,A Location in patent:Paragraph 0196-0197