2-Propenoic acid, 2-fluoro-3-(3-methoxyphenyl)-, (Z)- (9CI) synthesis
1synthesis methods
- Product Name:2-Propenoic acid, 2-fluoro-3-(3-methoxyphenyl)-, (Z)- (9CI)
- CAS Number:110915-37-2
- Molecular formula:C10H9FO3
- Molecular Weight:196.18
Yield:110915-37-2 71%
Reaction Conditions:
Stage #1: carbon dioxide;1-(2,2-difluorovinyl)-3-methoxybenzenewith copper(I) thiophene-2-carboxylate;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;bis(pinacol)diborane;lithium tert-butoxide in N,N-dimethyl-formamide at 80; under 760.051 Torr; for 24 h;
Stage #2: with hydrogenchloride in water;stereoselective reaction;
References:
Yan, Si-Shun;Wu, Dong-Shan;Ye, Jian-Heng;Gong, Li;Zeng, Xin;Ran, Chuan-Kun;Gui, Yong-Yuan;Li, Jing;Yu, Da-Gang [ACS Catalysis,2019,vol. 9,# 8,p. 6987 - 6992]