Methyl3-(2-hydroxyethyl)bicyclo[1.1.1]pentane-1-carboxylate synthesis

2synthesis methods

Product Name:Methyl3-(2-hydroxyethyl)bicyclo[1.1.1]pentane-1-carboxylate
CAS Number:1113001-65-2
Molecular formula:C9H14O3
Molecular Weight:170.21

83249-10-9 Synthesis

Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid, MonoMethyl ester

83249-10-9
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Methyl3-(2-hydroxyethyl)bicyclo[1.1.1]pentane-1-carboxylate

1113001-65-2
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / -15 °C / Inert atmosphere
1.2: 24.5 h / -4 - 0 °C
1.3: 0.5 h / 20 °C / Sonication
2.1: borane-THF / tetrahydrofuran / 6 h / -15 °C

References:

Filosa, Rosanna;Carmela Fulco;Marinozzi, Maura;Giacche, Nicola;Macchiarulo, Antonio;Peduto, Antonella;Massa, Antonio;de Caprariis, Paolo;Thomsen, Christian;Christoffersen, Claus T.;Pellicciari, Roberto [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 1,p. 242 - 250]

2-(3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl)acetic acid

1113001-63-0
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1113001-65-2
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References