4-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE synthesis

Yield:111661-47-3 94%

Reaction Conditions:

with hydrogenchloride;hydrogen;platinum(IV) oxide in methanol at 20; under 2250.23 Torr; for 4 h;

Steps:

69

4-methyl-1,2,3,4-tetrahydro-isoquinolin hydrochloride In a hydrogen atmosphere 0.50 g (3.5 mmol) 4-methyl-isoquinoline, 50 mg platinum dioxide in 50 mL methanol and 3.5 mL 1M aqueous hydrochloric acid solution were hydrogenated at RT and 3 bar for 4 h. After removal of the catalyst by suction filtering the reaction mixture was evaporated down. A mixture of educt and product was obtained, which was reacted further without any further purification. Yield: 0.60 g (94% of theory) ESI-MS: m/z=148 (M+H)⁺

References:

US2011/195954,2011,A1 Location in patent:Page/Page column 104-105