2-amino-1-(4-chloro-2-fluorophenyl)ethan-1-one hydrochloride synthesis
- Product Name:2-amino-1-(4-chloro-2-fluorophenyl)ethan-1-one hydrochloride
- CAS Number:1117843-10-3
- Molecular formula:C8H8Cl2FNO
- Molecular Weight:224.0596
1118245-74-1
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Yield:1117843-10-3 31%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 50; for 5 h;
Steps:
1
To a solution of the bromide compound (24 g, 90 mmol) in acetonitrile (300 mE) was added sodium diformylamide (9.0 g, 95 mmol). The mixture was heated to reflux for 2 h and cooled to tt overnight. The mixture was filtered to remove Nal3t The filtrate was concentrated to give diformylamide intermediate as a brown oil, 23.6 g. EtOR (300 mE) and 30% HC1 (90 mE) were added and the mixture was stirred at 500 C. for 5 h and cooled to room temperature overnight, during which time the product crystallized out. The solid was collected by filtration, washed with dichloromethane, and dried to constant weight to give the desired aminoketone hydrochloride as white solid (6.3 g, 31%). that was sued as is in the next step.
References:
US2018/228158,2018,A1 Location in patent:Paragraph 0311; 0320
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