3-(4-methyl-1,3-thiazol-2-yl)propan-1-amine(SALTDATA: 2HCl) synthesis

Yield:112086-66-5 93%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

Crude thiazole from above was dissolved in dichloromethane (2 mL, anhydrous) under argon at rt and treated with TFA (2 mL, anhydrous). The mixture stirred for 1 h and was then concentrated in vacuo to give a crude brown oil from which 3-(4-Methylthiazol-2-yl) propylamine (236 mg, 93% from thioamide) was isolated by flash chromatography (MeOH 0-20% in dichloromethane).

References:

US2004/87601,2004,A1 Location in patent:Page 29