ChemicalBook CAS DataBase List (2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide synthesis

3synthesis methods

Product Name:(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide
CAS Number:113181-02-5
Molecular formula:C12H10BrF3N2O2
Molecular Weight:351.12

654-70-6 Synthesis

654-70-6
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(2S)-3-Bromo-2-hydroxy-2-methylpropanoic acid

106089-20-7
36 suppliers
$60.00/10mg

(2S)-3-BroMo-N-[4-cyano-3-(trifluoroMethyl)phenyl]-2-hydroxy-2-Methyl-propanaMide

113181-02-5
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Yield:113181-02-5 90%

Reaction Conditions:

with dichlorosulfoxide;triethylamine

Steps:

6 (S)-3-Bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide(C₁₂H₉F₃N₂O₂)

(S)-3-Bromo-2-hydroxy-2-methylpropanoic acid (1.00 g, 0.0054645 mol) reacted with thionyl chloride (0.78 g, 0.0065574 mol), trimethylamine (0.72 g, 0.0071038 mol), and 4-amino-2- (trifluoromethyl)benzonitrile (1.02 g, 0.0054645 mol) to afford the titled compound.The product was purified by a silica gel column using DCM and ethyl acetate (19:1) as eluent to afford 1.75 g (90%) of the titled compound as a yellowish solid.Mass (ESI, Positive): 351.08 [M+Na]⁺.

References:

WO2019/222556,2019,A1 Location in patent:Paragraph 00479-00481

Propanoyl chloride, 3-bromo-2-hydroxy-2-methyl-, (2S)-

1010729-05-1
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654-70-6 Synthesis

654-70-6
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113181-02-5
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References

75-09-2 Synthesis

75-09-2
1199 suppliers
$10.00/25ML

654-70-6 Synthesis

654-70-6
460 suppliers
$5.00/1g

106089-20-7
36 suppliers
$60.00/10mg

141-78-6 Synthesis

141-78-6
611 suppliers
$22.37/250ml

113181-02-5
7 suppliers
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References