ChemicalBook CAS DataBase List 5-BroMo-2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

5-BroMo-2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine synthesis

2synthesis methods

Product Name:5-BroMo-2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
CAS Number:1131992-13-6
Molecular formula:C7H4BrCl2N3
Molecular Weight:280.94

90213-67-5 Synthesis

2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

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5-BroMo-2,4-dichloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine

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Yield:1131992-13-6 96%

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane at 20;

Steps:

Step 2

Step 2: To a stirred solution of 2,4-dichloro-7-methyl-7/-/-pyrrolo[2,3-c]pyrimidine (2.06 g, 10.198 mmol) in dichloromethane (20 mL) was added /V-bromosuccinimide (2.17 g, 12.237 mmol) in one portion at room temperature, and the reaction was stirred overnight. The reaction mixture was concentrated and water was added to the residue. The precipitated solid was filtered and dried under vacuo to obtain 5-bromo-2,4-dichloro-7-methyl-7/-/-pyrrolo[2,3- cdpyrimidine as an off white solid (2.76 g, 96 %). LCMS (ES) m/z = 279.9, 281.9 [M+H]⁺. H NMR (400 MHz, DMSO-d6) δ ppm 3.84 (s, 3H), 7.24 (s, 1 H).

References:

WO2017/46739,2017,A1 Location in patent:Page/Page column 51

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References