ChemicalBook CAS DataBase List Benzenepropanoic acid, β-cyclopropyl-3-hydroxy-, Methyl ester, (βS)-

Benzenepropanoic acid, β-cyclopropyl-3-hydroxy-, Methyl ester, (βS)- synthesis

5synthesis methods

Product Name:Benzenepropanoic acid, β-cyclopropyl-3-hydroxy-, Methyl ester, (βS)-
CAS Number:1142223-08-2
Molecular formula:C13H16O3
Molecular Weight:220.26

100-83-4
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Benzenepropanoic acid, β-cyclopropyl-3-hydroxy-, Methyl ester, (βS)-

1142223-08-2
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$288.00/1g

1142223-06-0 Synthesis

(βR)-β-cyclopropyl-3-hydroxy-Benzenepropanoic acid methyl ester

1142223-06-0
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: water / 2 h / 85 °C
2: tetrahydrofuran / 0.5 h / 0 - 20 °C
3: water / N,N-dimethyl-formamide / 90 °C
4: sulfuric acid / Reflux

References:

Brown, Sean P.;Dransfield, Paul J.;Vimolratana, Marc;Jiao, Xianyun;Zhu, Liusheng;Pattaropong, Vatee;Sun, Ying;Liu, Jinqian;Luo, Jian;Zhang, Jane;Wong, Simon;Zhuang, Run;Guo, Qi;Li, Frank;Medina, Julio C.;Swaminath, Gayathri;Lin, Daniel C.-H.;Houze, Jonathan B. [ACS Medicinal Chemistry Letters,2012,vol. 3,# 9,p. 726 - 730]