ChemicalBook CAS DataBase List [1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester synthesis

4synthesis methods

Product Name:[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester
CAS Number:114488-91-4
Molecular formula:C31H27F3O6
Molecular Weight:552.54

54142-64-2 Synthesis

[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-5-yl ester

54142-64-2
54 suppliers
inquiry

[1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2-oxo-2H-cyclopenta[b]furan-5-yl ester

114488-91-4
16 suppliers
inquiry

Yield:114488-91-4 73.51%

Reaction Conditions:

with (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole;benzo[1,3,2]dioxaborole in dichloromethane at -7 - 28; for 3 h;

Steps:

2.4 Step 4: Preparation of compound of formula III {(3aR, 4R, 5R, 6aS) -4 - ((R, E) -3- hydroxy- 4- (3- (trifluoromethyl) phenoxy) Enyl) -2-oxohexahydro-2H-cyclopenta [b] furan-5-ylbiphenyl-4- carboxylate}

Catecholborane (2.29 g, 19.072 mmol, 2.1 eq) was dissolved in 30 mL of methylene chloride. R-Me CBS (1M Tol) (6 mL, 5.994 mmol, 0.66 eq) was added dropwise at 28 deg C; 0 deg C for 5 min. Compound (II) (5 g, 9.082 mmol) prepared in Step 3 at -7 ° C was dissolved in 30 mL of methylene chloride and added dropwise for 1 hour and stirred for 2 hours. The organic layer was washed with 50 mL of water and 100 mL of a 10% NaCl solution. The organic layer was further washed with brine (100 mL), and the organic layer was dried over anhydrous, and then the solvent was concentrated under reduced pressure. The yellowish oil was collected by column chromatography with ethyl acetate: hexane = 1: 1 to give a yellow oil (3.69 g, 73.51%).

References:

KR2017/25682,2017,A Location in patent:Paragraph 0136; 0154-0156

Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate

54094-19-8
125 suppliers
$65.00/1g

114488-91-4
16 suppliers
inquiry

References

[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-4-formylhexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester

38754-71-1
42 suppliers
inquiry

114488-91-4
16 suppliers
inquiry

References

31752-99-5 Synthesis

(-)-Corey lactone 4-phenylbenzoate alcohol

31752-99-5
247 suppliers
$19.00/250mg

114488-91-4
16 suppliers
inquiry

References