6-Chloro-3-cyclopropyl-[1,2,4]triazolo[4,3-b]pyridazine synthesis
- Product Name:6-Chloro-3-cyclopropyl-[1,2,4]triazolo[4,3-b]pyridazine
- CAS Number:1152552-07-2
- Molecular formula:C8H7ClN4
- Molecular Weight:194.62
105484-43-3
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1152552-07-2
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Yield:1152552-07-2 170 mg
Reaction Conditions:
with acetic acid in toluene at 120; for 0.5 h;Microwave irradiation;
Steps:
8 Synthesis of A-9:
A mixture of A-2 (200.00 mg, 1.38 mmol) and cyclopropanecarbonyl chloride (150.54 _^, 1.66 mmol) in toluene (10 mL) was stirred at 100 C for 12 hour. This mixture was concentrated and AcOH (10 mL) was added to the residue. The mixture was stirred at 120 C for 0.5 hour in a microwave reactor, then the mixture was concentrated, diluted with H20 (10 mL), basified with solid NaHC03 to pH ~ 9, extracted with EtOAc (30 mL x 2), and the combined organic phase was washed with brine (10 mL), dried over Na2S04, filtered and concentrated to give crude A-9 (170.00 mg). LCMS Rt = 0.64 min using Method B, MS ESI calcd. for C8H8C1N4 [M+H]+194.9, found 195.0.
References:
WO2018/98499,2018,A1 Location in patent:Page/Page column 125
17284-97-8
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1759-53-1
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1152552-07-2
18 suppliers
$65.00/50mg