2-chloro-5-[(methylsulfonyl)methyl]pyridine(SALTDATA: FREE) synthesis

2synthesis methods

Product Name:2-chloro-5-[(methylsulfonyl)methyl]pyridine(SALTDATA: FREE)
CAS Number:1158608-08-2
Molecular formula:C7H8ClNO2S
Molecular Weight:205.66

1021870-94-9 Synthesis

2-chloro-5-[(methylthio)methyl]pyridine(SALTDATA: FREE)

1021870-94-9
10 suppliers
$60.00/50mg

2-chloro-5-[(methylsulfonyl)methyl]pyridine(SALTDATA: FREE)

1158608-08-2
10 suppliers
$220.00/500mg

Yield:1158608-08-2 76%

Reaction Conditions:

with 3-chloro-benzenecarboperoxoic acid in dichloromethane at 0 - 20;

Steps:

13.2 STEP 2: 2-chloro-5-((methylsulfonyl)methyl)pyridine

3-chlorobenzenecarboperoxoic acid (77%, 653 mg, 2.91 mmol)^was added to a solution of^2-chloro-5-((methylthio)methyl)pyridine (220 mg, 1.27 mmol)^in^dichloromethane (9 mL) at 0°C. The cooling bath was removed and the solution was stirred at room temperature overnight. The mixture was diluted with dichloromethane, washed with 10% aqueous potassium carbonate solution, dried with magnesium sulfate, and concentrated. The residue was chromatographed on^prep-TLC (cyclohexane:ethyl acetate; 3:7) to yield 2-chloro-5-((methylsulfonyl)methyl)pyridine (199 mg, 76%)^as a solid.

References:

WO2021/211741,2021,A1 Location in patent:Paragraph 0212

70258-18-3 Synthesis

70258-18-3
507 suppliers
$5.00/5g

1158608-08-2
10 suppliers
$220.00/500mg

References